Stephen Senn: Blogs and Web Papers

This page provides a link to various blogs of mine and also to papers of mine that are readily available on the web. On the whole the papers are didactic in nature.

A companion page on Data Sets may also be of interest

Navigation

COVID19
Evidence Based Medicine
Experimental Design
History
Inference
Miscellaneous
Personalised Medicine
Professional
Randomisation
Teaching

Blogs and Papers

Type Topic Title Keywords

COVID19

Blog COVID19 Heard Immunity COVID19; Clinical Trials; Sequential Analysis; Vaccines; Pfizer/BioNTech; AZ/Oxford; Moderna
Blog COVID19 Stimulated to simulate COVID19; Clinical Trials; Sequential Analysis
Blog COVID19 A Vaccine Trial from A to Z COVID19; Clinical Trials; Vaccines; Inference; AZ/Oxford
Blog COVID19 A Vaccine Trial from A to Z: with a Postscript COVID19; Clinical Trials; Vaccines;Inference;AZ/Oxford;Pfizer/BioNTech
Blog COVID19 Doubling Up COVID19; Clinical Trials; Vaccines; Inference; Pfizer/BioNTech; Moderna
Blog COVID19 Infectious Enthusiasm COVID19; Clinical Trials; Vaccines; Inference; Pfizer/BioNTech
Blog COVID19 Serendipity Dividend? COVID19; Clinical Trials; Vaccines;Inference; Dose Response; AZ/Oxford
Blog COVID19 Needlework Guesswork COVID19; Clinical Trials; Vaccines; Inference; Reverse Engineering; AZ/Oxford
Blog COVID19 Complicated COVID comparisons COVID19; Clinical Trials; Vaccines;Inference;AZ/Oxford
Blog COVID19 Of Weighting and Waiting COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Blind Date COVID19; Clinical Trials; Vaccines;Inference
Blog COVID19 Beta Testing COVID19; Clinical Trials; Vaccines;Inference; Bayesian; Pfizer/BioNTech
Blog COVID19 Straining for Effect COVID19; Clinical Trials; Vaccines;Inference; New variant COVID-19; Novavax
Blog COVID19 Dilly-Dally Delay? COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford; Booster shot
Blog COVID19 Credible Confidence COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech; Bayesian
Blog COVID19 A Very Standard Error COVID19; Clinical Trials; Vaccines;Inference;Pfizer/BioNTech; Moderna; AZ/Oxford; Concurrent Control
Blog COVID19 Phase Change COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Hold that Result COVID19; Clinical Trials; Vaccines;Inference; AZ/Oxford
Blog COVID19 Youthful Enthusiasm COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech
Blog COVID19 Going Viral COVID19; Clinical Trials; Vaccines;Inference; Pfizer/BioNTech; AZ/Oxford; Moderna; Novavax; J&J Janssen
Blog COVID19 Screen Test COVID19; Screening; Bayes theorem; Sensitivity; Specificity; Positive Predictive Value; Negative Predictive Value
Blog COVID19 Indian Summer COVID19; Vaccine Efficacy; Viral Strains; Pfizer/BioNTech; AZ/Oxford; Indian variant
Blog COVID19 Scale Fail COVID19; Vaccine Efficacy; Measurement; Pfizer/BioNTech; AZ/Oxford; Moderna; J&J Janssen; Novavax
Blog COVID19 Trials of COVID-19 vaccines: what can be learnt for the development of new antimicrobials? COVID19; Vaccine Efficacy; Pfizer/BioNTech; AZ/Oxford; Moderna; J&J Janssen; Novavax; Historical controls; Design of Experiments

Evidence Based Medicine

Blog Evidence Based Medicine It's publishing, Jim, but not as we know it Publication bias; open data
Blog Evidence Based Medicine Fishing for Fakes with FisherFraud; Randomisation
Paper Evidence Based Medicine Publication Bias: Editors are not Blameless after allPublication bias
Paper Evidence Based Medicine Authors are also reviewersPublication bias
Paper Evidence Based Medicine Overstating the EvidenceMeta-analyis; Standard Errors
Paper Evidence Based Medicine Sharp tongues and bitter pillsEthics; Pharmaceutical industry; Meta-analysis; Publication bias; Conflict of Interest
Blog Evidence Based Medicine Open seasonData-sharing
Blog Evidence Based Medicine Is Pooling FoolingMeta-Analysis
Blog Evidence Based Medicine Bad PharmaPharmaceutical industry; Ethics; Missing data; Data filters
Blog Evidence Based Medicine Two CulturesPharmaceutical industry; Drug Regulation; Clinical Trials;Statistical Analysis

Experimental Design

Blog Experimental Design Delta ForcePower; Sample size; Clinical trials
Blog Experimental Design Rothamsted Statistics meets Lord's ParadoxCausal Analysis; Components of Variation; Analysis of Variance
Blog Experimental Design On the LevelCausal Analysis; Components of Variation; General Balance;Block Structure; Analysis of Variance
Blog Experimental Design To Infinity and BeyondBig data; Clinical trials; Randomisation; Standard Error; Analysis of Variance
Blog Experimental Design Red Herrings and the Art of Cause FishingCausal Analysis; Components of Variation
Paper Experimental Design The Misunderstood PlaceboEthics; Control; Clinical Trials; Equipoise
Blog Experimental Design Fooling the Patient: an Unethical Use of Placebo?Ethics; Control; Clinical Trials; Equipoise
Blog Experimental Design Placebos: It's not only the Patients that are FooledEthics; Control; Clinical Trials; Equipoise
Paper Experimental Design The AB/BA Cross-over: How to perform the two-stage analysis if you can't be persuaded that you shouldn't Cross-over Trial; Clinical Trials; Carry-Over; Testing Assumptions; Inference
Paper Experimental Design An Incomplete Blocks Trial in Asthma Cross-over Trial; Clinical Trials;Incomplete Blocks; Dose-Finding; Inference Parallel Assay
Paper Experimental Design Lessons from TGN 1412 Clinical Trials; Dose-Finding; Ethics; Trend Effects; Inference; First-in-Man
Paper Experimental Design Safety First Clinical Trials; Dose-Finding; Ethics; Trend Effects; Inference; First-in-Man
Blog Experimental Design Blood simpleBioequivalence; Two-sided tests; One-sided tests; Clinical Trials; Confidence Intervals
Blog Experimental Design Making it personal: N-of-1 trials, allowing for individuality but not overdoing itClinical Trials; Random Effects; Shrinkage; Mixed Models;Personalised Medicine
Blog Experimental Design Testing Times Clinical Trials; Cross-over Trials; Inference; Recogniseable Subsets; Testing Assumptions; Screening
Blog Experimental Design t for Two Drug Development; Clinical Trials; Inference; COVID19; meta-analysis
Blog Experimental Design Designed Inferences Clinical Trials; Inference; Components of Variation; Cross-over Trials
Paper Experimental Design Giving and taking: ethical treatment assignment in controlled trials. (With Iain Chalmers) Clinical Trials; Ethics; Placebos
Paper Experimental Design Confounder Confusion Confounding; Random effects; Observational studies;History of Statistics
Paper Experimental Design Studying the Effects of Studies Concurrent control; Randomised Clinical Trials; Effects of time; Effects of place; Study effects
Blog Experimental Design The Rule of Three Block effects; Treatment effects; Randomisation; Factorial designs; Components of variation
Blog Experimental Design Design of Experiments: a Tentataive Timeline Block effects; Treatment effects; Randomisation; Factorial designs; Optimal Design; Quality
Blog Experimental Design More or Less or Not at All Concurrent control; Placebos; Treatment effects
Blog Experimental Design A Standard Error Randomisation; Random Sampling; Inference; Clinical Trials;Graphics
Blog Experimental Design A Tragedy of Errors Clinical Trials;Analysis of Covariance; Modelling; Regression Dilution; Errors in Variables
Blog Experimental Design Design or Model? Which determines the analysis? Clinical Trials;Analysis of Covariance; Modelling;
Blog Experimental Design Power to the difference Clinical Trials;Sample size; Cross-over trials; SAS
Blog Experimental Design A Dose of Common Sense Clinical Trials;Bioequivalence;Dose Proportionality
Blog Experimental Design Unfair Comparisons? Clinical Trials;Causal Inference;Statistical Inference; Assumptions
Blog Experimental Design Halls of Fame Cluster Allocation;Causal Inference;Statistical Inference; Assumptions
Blog Experimental Design Replication Crisis Cluster Allocation;Causal Inference;Statistical Inference; Assumptions;Lord's Paradox; Pseudoreplication
Podcast Experimental Design Ep. 157 Stephen Senn: N-of-1 Trials and Beyond Accad and Koka Report; N-of-1 Trials
Blog Experimental Design A Random TrioCausal Inference;Statistical Inference; Random Effects;History of Statistics
Blog Experimental Design Lauding LordLord's Paradox; Causal Inference;Statistical Inference; Uncertainty;History of Statistics
Blog Experimental Design Lauding Lord: a PostcriptLord's Paradox; Causal Inference;Statistical Inference; Uncertainty;History of Statistics
Blog Experimental Design Bias BindingFixed Effects; Random Effects;Causal Inference;Statistical Inference; Efficiency;Linear Combinations
Paper Experimental Design The analysis of continuous data from n-of-1 trials using paired cycles: a simple tutorialFixed Effects; Random Effects;Causal Inference; shrunk estimates;meta-analysis

History

Paper History Cushny and Peebles, optical isomers, and the birth of modern statistics. Student; t-test; n-of-1 trials
Paper History A century of t-tests Student; t-test; n-of-1 trials
Paper History The t-test tool Student; t-test; n-of-1 trials
Paper History Francis Galton and Regression to the Mean Genetics; Correlation
Paper History Tea for three. Fisher; Randomisation; Blinding; Experimental Design; Inference
Paper History Student and the Lanarkshire Milk Experiment Experimental Design; Randomisation;Components of Variation;Nutrition
Paper History An Early 20th Century Handbook on 'Meta-analysis': David Brunt's The Combination of Observations Meta-analysis; Least squares; Measurement

Inference

Blog Inference Automatic for the people Bayes Factors; Two Trials Rule; Significance
Blog Inference Dawid's Selection Paradox Bayesian; Conjugate Prior; Hierarchical Model
Blog Inference A Paradox of Prior ProbabilitiesBayesian; Conjugate Prior; Hierarchical Model
Blog Inference Fisher's Alternative to the AlternativeHistory of Statistics; Significance Test
Blog Inference Also Smith and Jones Bayesian; Sequential Analysis
Blog Inference The irrelevance of stopping rules in meta-analysisSequential Analysis; Meta-Analysis; Weighting; Evidence
Blog Inference The Pathetic P-valueBayesian; Frequentist; Significance
Blog Inference Double JeopardyBayesian; Frequentist; Significance
Blog Inference When relevance is irrelevant Additivity; Statistical Analysis; Survival Analysis; Numbers Needed to Treat; Personalised Medicine
Paper Inference Bayesian, Likelihood,and FrequentistApproaches to Statistics Tutorial; Bayesian; Frequentist; Clinical Trials; Drug Development
Paper Inference Invalid Inversion Regression to the Mean; Error of the Transposed Conditional; Bayesian
Paper Inference You may Believe you are a Bayesian but you are Probably Wrong Bayesian; Jeffreys; Fisher; De Finetti; Neyman-Pearson
Blog Inference The nuisance parameter nuisance Cross-over trials; Testing assumptions; Pre-testing; Carry-over
Blog Inference The importance of knowing how much you don't know Standard Errors; History of Statistics; Meta-analysis; Confidence Intervals;Experimental Design
Blog Inference Of Amazons, Martingales, Rogue Traders and Sequential Analysis Meta-analysis; Sequential Analysis; Martingales;Clinical trials
Blog Inference Dichotomania Measurement; Efficiency; Information;Clinical trials
Blog Inference Being Wrong about Efficacy Probabilities Clinical trials; Randomisation; Causal Inference; Prediction
Blog Inference Cause for Concern Causal Inference; Mixed models; Design of Experiments; Lord's Paradox
Video Inference What is your question? Causal and predictive purposes of clinical trials and the implications for analysis Causal Inference; Mixed models; Prediction
Blog Inference The Many Halls Problem Causal Inference; Mixed models; Lord's Paradox; Design of Experiments
Blog Inference Margins of Error Significance testing; Replication; P-values
Blog Inference Trends towards non-significance Significance testing; P-values; Fragility Index
Blog Inference The mean side of the force: How regression to the mean can fool us Inference; Concurrent Control; Bias; Causality
Blog Inference Being Just about Adjustment in Clinical Trials Inference; Likelihood; Modelling; Bias; Causality; ANCOVA

Miscellaneous

Paper Miscellaneous Comets, Contagion and ContingencyInfectious diseases; Stochastic Processes; Cometary Hypothesis

Personalised Medicine

Blog Personalised Medicine Personal Perils Numbers Needed to Treat; Precision Medicine; Personalised Medicine
Blog Personalised Medicine 30 Years of Numbers Needed to TreatNumbers Needed to Treat; Precision Medicine; Personalised Medicine
Blog Personalised Medicine Painful Dichotomies Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual
Program Personalised Medicine NNT Simulator and Calculator Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual
Blog Personalised Medicine Responder Despondency Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual; Zombie Statistics
Paper Personalised Medicine Statistical pitfalls of personalized medicine Numbers Needed to Treat; Precision Medicine; Personalised Medicine; Exponential Distribution; Counterfactual; Zombie Statistics
Paper Personalised Medicine Three Things Every Medical Writer Should Know About Statistics Regression to the Mean; Invalid Inversion; Precision Medicine; Personalised Medicine;
Paper Personalised Medicine Mastering Variation Responder fallacy; Personalised Medicine; Components of Variation; Quality; Counterfactuals
Blog Personalised Medicine Evidence Based or Person-centred? A Statistical debate (Guest Post) Precision Medicine; Personalised Medicine; Bioequivalence; n-of-1 Trials
Blog Personalised Medicine The Power of Negative Thinking Clinical Trials; Personalised Medicine; Power;Subgroups;Responders;Critical Care
Blog Personalised Medicine Finding excuses Clinical Trials; Personalised Medicine; Power;Subgroups;Responders;Critical Care
Blog Personalised Medicine Invisible Statistics Clinical Trials; Personalised Medicine; Subgroups; Responders; Bioequivalence; Sex inequality
Blog Personalised Medicine Fair Shares: Sexual Justice in Patient Recruitment in Clinical Trials Clinical Trials; Personalised Medicine; Subgroups; Sex inequality; Ethics
Blog Personalised Medicine It's harder than you think Clinical Trials; Personalised Medicine; Responder Analysis

Professional

Blog Professional On Being a Consultant (Medical) Statistician Consulting; Pharmaceutical Industry

Randomisation

Blog Randomisation Randomisation, Ratios and RationalityClinical Trials; Analysis of Variance; Randomisation
Paper Randomisation The Well-adjusted StatisticianClinical Trials; Analysis of Covariance; Randomisation
Blog Randomisation Being a statistician means never having to say you are certain Clinical Trials; Analysis of Variance; Randomisation; Causal Analysis
Blog Randomisation Indefinite IrrelevanceClinical Trials; Analysis of Variance; Randomisation; Causal Analysis
Paper Randomisation Baseline Balance and Valid Statistical AnalysesClinical Trials; Analysis of Variance; Randomisation
Blog Randomisation Stop Obesessing about BalanceClinical Trials; Analysis of Variance; Randomisation
Blog Randomisation Being Just about AdjustmentClinical Trials; Analysis of Covariance; Randomisation; Baselines
InterviewRandomisation 70 Years and Still Here: The Randomized Clinical Trial and its CriticsClinical Trials; Analysis of Variance; Randomisation
BlogRandomisation Randomisation is not about balance, nor about homogeneity but about randomnessClinical Trials; Analysis of Variance; Randomisation, Incomplete blocks, Confidence Intervals
BlogRandomisation Balance is not the issueClinical Trials; Analysis of Variance; Randomisation; Incomplete blocks; Confidence Intervals
BlogRandomisation Losing controlClinical Trials; Analysis of Variance; Randomisation; Concurrent Control; Historical Controls; COVID-19
VideoRandomisation Being wrong about randomisationClinical Trials; Analysis of Variance; Randomisation;Uncertainty;Standard Errors
BlogRandomisation Balancing the view on BalanceClinical Trials; Analysis of Variance; Randomisation;Uncertainty;Standard Errors;Balance
BlogRandomisation Random, yes, but sampling or isation?Clinical Trials; Randomisation; Experiments;Surveys; Random sampling
BlogRandomisation Pair ShapedClinical Trials; Randomisation; Experiments
BlogRandomisation Shaped PairsClinical Trials; Randomisation; Experiments
BlogRandomisation Second Things FirstClinical Trials; Randomisation; Experiments; Causal Inference; Propensity Score

Teaching

BlogTeaching On thinking and learningUniversities; Undergraduate Education
ProgramTeaching Logistic exam mark rescalerExaminations; Assessment; Logistic Regression

Page of links to Stephen Senn's Statistics notes

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This page last updated 16 June 2024

Page maintained by Stephen Senn stephen@senns.uk