**Selected Programs to Accompany the Second Edition of**

**Cross-over Trials in Clinical Research**

*Stephen Senn*

**Disclaimer**: I am not an
expert programmer and I give no guarantees regarding the accuracy, still less
the elegance of these programs. All and any of these programs are used at the
user's risk.

Stephen Senn

**Programs in various languages**

Example 9.3 (Design)

Example 9.3 (Analysis: The data from this
example are not included in the book. The example is covered in detail in the
paper by Senn, Lillienthal, Patalano and Till referenced in the book.)

Sample size
program (This program calculates sample size for an AB/BA cross-over)

Example 7.3
(The GenStat analysis of this example is not
illustrated in the book)

Example 9.3 (Design. **Caution:** while this works, I think, for
this particular example it is not a general method for constructing such
designs)

Example 9.3
(Analysis: The data from this example are not included in the book. The example
is covered in detail in the paper by Senn, Lillienthal,
Patalano and Till referenced
in the book.)

Sample size
program (This program calculates sample size for an AB/BA cross-over)

Example
4.3
(This example uses the MASS library of Venables and
Ripley and is not illustrated in the book.)

Example
7.3 ( The SPlus analysis of this
example is not illustrated in the book. In order to run this program it will be
necessary to download this data file also Example
7.3 Data )

Example
9.3 (Analysis: The data from this example are not
included in the book. The example is covered in detail in the paper by Senn, Lillienthal, Patalano
and Till referenced in the book. In order to run this program it will be
necessary to download this data file also Example
9.3 Data )

*These
programs were adapted from S-Plus with the help of Anna Schritz.
R is not included in the book. Some of the programs are identical to the SPlus ones. Where that is so the link is to the SPlus file*

Example 4.3 (This
example uses the MASS library of Venables and Ripley
and is not illustrated in the book.)

Example 7.3 ( In order to run this program it will be necessary to
download this data file also Example 7.3
Data
)

Example 9.3 (Analysis: The data from this example
are not included in the book. The example is covered in detail in the paper by
Senn, Lillienthal, Patalano and Till referenced in the book. In order to
run this program it will be necessary to download this data file also Example 9.3 Data )

Sample size program (This
program calculates sample size for an AB/BA cross-over)

The use of Mathcad is not
covered in the book. However, I find it very useful for many theoretical
investigations. The program below can be used to determine sample size for any
arbitrary cross-over design. It is especially useful for incomplete block
designs and gives the option of recovering inter-block information.

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Page last updated 29 April
2020